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Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with a-linolenic acid in a rat model of inflammatory bowel disease

This study investigates the impact of varying ratios of dietary linoleic acid (LA, 18:2n-6) to a-linolenic acid (ALA, 18:3n-3) on the inflammatory response in dextran sulphate sodium (DSS)-induced colitis. The smallest ratio of LA with ALA (LA:ALA ratio 2) mitigates experimental colitis the most compared to the larger ratios of LA to ALA by down-regulating proinflammatory mediators. Read more »

Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-κB in rats with TNBS-induced colitis

This study aimed to evaluate the efficacy of the dual therapy (n-3 PUFA plus 5-ASA) in rats with 2, 4, 6-trinitrobenzen sulfonic acid (TNBS)- induced colitis. The results indicate that the dual therapy is more effective than a higher dose of 5-ASA alone to reduce NF-κB activation and to induce PPARγ, but it did not improve the effects of individual treatments on eicosanoids or cytokine production. Read more »

Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity

In this study, researchers found that the loss of an environmental sensor in intestinal sentinel cells under steady state conditions is associated with abnormal intestinal epithelial development and aberrant Wnt signalling in these APCs. Further, DCs and macrophages may play a role in modulating Wnt signalling of cells that are anatomically near or in close proximity such as the IECs Read more »

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Latest research findings regarding IBD