In this study, a rat model of TNBS colitis, which mimics human IBD was used. The researchers determined that medium-chain TAG is most successful in reducing inflammation in the intestinal mucosa compared to both long-chain and baseline TAG. Read more »
Anti-Inflammatory Effects of Resveratrol, Curcumin and Simvastatin in Acute Small Intestinal Inflammation
Oral treatment with Resveratrol, Curcumin or Simvastatin improves acute small intestinal inflammation by down-regulating Th1-type immune responses and prevents bacterial translocation by maintaining gut barrier function. Specifically, Resveratrol prolongs survival rate in an acute ileitis model. Read more »
Butyrate acts as a survival factor for colonic epithelial cells: further fuel for the in vivo versus in vitro debate.
Lack of butyrate is associated with induction of Bax and subsequent apoptosis in the proximal colon of guinea pig. Read more »