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Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity

In this study, researchers found that the loss of an environmental sensor in intestinal sentinel cells under steady state conditions is associated with abnormal intestinal epithelial development and aberrant Wnt signalling in these APCs. Further, DCs and macrophages may play a role in modulating Wnt signalling of cells that are anatomically near or in close proximity such as the IECs Read more »

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Latest research findings regarding IBD