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Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis

This study showed that an iron sulfate free diet in combination with systemic iron repletion prevents the development of chronic ileitis in a murine model of Crohn's disease. Luminal iron may directly affect IEC function or generate a pathological milieu in the intestine that triggers epithelial cell stress-associated apoptosis through changes in microbial homeostasis. Read more »

Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis

Curcumin reduced neutrophil infiltration, lipid peroxidation, the levels of nitric oxide (NO) and oxygen associated with the favourable expression of Th1 and Th2 cytokines and inducible NO synthase. These findings suggest that curcumin or diferuloylmethane, a major component of the food flavour turmeric, exerts beneficial effects in experimental colitis and may, therefore, be useful in the treatment of IBD. Read more »

Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers

In the current report, researchers describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-a action and production in in vitro models, in animal models and in humans. In addition, they provide evidence for curcumin's activities against all of the diseases for which TNF blockers are currently being used. Read more »

Curcumin attenuates DNB-induced murine colitis

Curcumin, a component of the spice turmeric, is able to attenuate colitis in the dinitrobenzene sulfonic acid (DNB)-induced murine model of colitis. When given before the induction of colitis it reduced macroscopic damage scores and NF- B activation. This was accompanied by a reduction in myeloperoxidase activity, and using semiquantitative RT- PCR, an attenuation of the DNB-induced message for IL-1 was detected. Read more »

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Latest research findings regarding IBD