This study showed that an iron sulfate free diet in combination with systemic iron repletion prevents the development of chronic ileitis in a murine model of Crohn's disease. Luminal iron may directly affect IEC function or generate a pathological milieu in the intestine that triggers epithelial cell stress-associated apoptosis through changes in microbial homeostasis. Read more »
Curcumin reduced neutrophil infiltration, lipid peroxidation, the levels of nitric oxide (NO) and oxygen associated with the favourable expression of Th1 and Th2 cytokines and inducible NO synthase. These findings suggest that curcumin or diferuloylmethane, a major component of the food flavour turmeric, exerts beneficial effects in experimental colitis and may, therefore, be useful in the treatment of IBD. Read more »
This study has shown for the first time that treatment with curcumin can prevent and improve murine experimental colitis. This finding suggests that curcumin could be a potential therapeutic agent for the treatment of patients with inflammatory bowel disease. Read more »
Curcumin acts as an IFN-γ signaling inhibitor in colonocytes with biphasic mechanisms of action, a phenomenon that may partially account for the beneficial effects of curcumin in experimental colitis and in human IBD. Read more »
In the current report, researchers describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-a action and production in in vitro models, in animal models and in humans. In addition, they provide evidence for curcumin's activities against all of the diseases for which TNF blockers are currently being used. Read more »
Curcumin, a component of the spice turmeric, is able to attenuate colitis in the dinitrobenzene sulfonic acid (DNB)-induced murine model of colitis. When given before the induction of colitis it reduced macroscopic damage scores and NF- B activation. This was accompanied by a reduction in myeloperoxidase activity, and using semiquantitative RT- PCR, an attenuation of the DNB-induced message for IL-1 was detected. Read more »
