In this study, colitic rats fed sage oil diets had a lower inflammatory response, improved histological repair and had less necrotic damage in the mucosa when compared to rats fed food in the corn and fish oil groups. These results suggest that plant-derived oil rich in ALA could ameliorate the inflammatory damage in colitis. Read more »
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Our results provide biological insights into the pathogenesis of IBD and demonstrate the usefulness of trans-ancestry association studies for mapping loci associated with complex diseases and understanding genetic architecture across diverse populations. Read more »
Long-term dietary intake influences the structure and activity of the trillions of microorganisms residing in the human gut, but it remains unclear how rapidly and reproducibly the human gut microbiome responds to short-term macronutrient change. Read more »
Inflammatory bowel disease (IBD) is a complex, multi-factorial disease thought to arise from an inappropriate immune response to commensal bacteria in a genetically susceptible person that results in chronic, cyclical, intestinal inflammation. Read more »
The intestinal tract is inhabited by a large and diverse community of microbes collectively referred to as the gut microbiota. Read more »
Mammals exhibit marked interindividual variations in their gut microbiota, but it remains unclear if this is primarily driven by host genetics or by extrinsic factors like dietary intake. Read more »