This study investigates the impact of varying ratios of dietary linoleic acid (LA, 18:2n-6) to a-linolenic acid (ALA, 18:3n-3) on the inflammatory response in dextran sulphate sodium (DSS)-induced colitis. The smallest ratio of LA with ALA (LA:ALA ratio 2) mitigates experimental colitis the most compared to the larger ratios of LA to ALA by down-regulating proinflammatory mediators. Read more »
In this study, the purified enzyme was able to transaminate hypotaurine (2-aminosulfinate), taurine, b-alanine and with low activity cysteine and 3-aminopropanesulfonate. In addition to pyruvate, 2-ketobutyrate and oxaloacetate were utilized as amino group acceptors. Read more »
In this study, diets modified specific cecal microbiota, which indicates that these changes were not associated with colitis reduction. Intestinal inflammation was positively correlated to protein fermentation and negatively correlated with carbohydrate fermentation in the large intestine. Read more »
In this study, colitic rats fed sage oil diets had a lower inflammatory response, improved histological repair and had less necrotic damage in the mucosa when compared to rats fed food in the corn and fish oil groups. These results suggest that plant-derived oil rich in ALA could ameliorate the inflammatory damage in colitis. Read more »
This study aimed to evaluate the efficacy of the dual therapy (n-3 PUFA plus 5-ASA) in rats with 2, 4, 6-trinitrobenzen sulfonic acid (TNBS)- induced colitis. The results indicate that the dual therapy is more effective than a higher dose of 5-ASA alone to reduce NF-κB activation and to induce PPARγ, but it did not improve the effects of individual treatments on eicosanoids or cytokine production. Read more »
In this study, researchers found that the loss of an environmental sensor in intestinal sentinel cells under steady state conditions is associated with abnormal intestinal epithelial development and aberrant Wnt signalling in these APCs. Further, DCs and macrophages may play a role in modulating Wnt signalling of cells that are anatomically near or in close proximity such as the IECs Read more »
