In this study, a rat model of TNBS colitis, which mimics human IBD was used. The researchers determined that medium-chain TAG is most successful in reducing inflammation in the intestinal mucosa compared to both long-chain and baseline TAG. Read more »
Oral treatment with Resveratrol, Curcumin or Simvastatin improves acute small intestinal inflammation by down-regulating Th1-type immune responses and prevents bacterial translocation by maintaining gut barrier function. Specifically, Resveratrol prolongs survival rate in an acute ileitis model. Read more »
Lack of butyrate is associated with induction of Bax and subsequent apoptosis in the proximal colon of guinea pig. Read more »
Our results provide biological insights into the pathogenesis of IBD and demonstrate the usefulness of trans-ancestry association studies for mapping loci associated with complex diseases and understanding genetic architecture across diverse populations. Read more »
Long-term dietary intake influences the structure and activity of the trillions of microorganisms residing in the human gut, but it remains unclear how rapidly and reproducibly the human gut microbiome responds to short-term macronutrient change. Read more »
Inflammatory bowel disease (IBD) is a complex, multi-factorial disease thought to arise from an inappropriate immune response to commensal bacteria in a genetically susceptible person that results in chronic, cyclical, intestinal inflammation. Read more »