In clinically quiescent Crohn's disease, altering dietary FODMAP intake is associated with marked changes in fecal microbiota, most consistent with a prebiotic effect of increasing FODMAPs as shown in an irritable bowel/healthy cohort. This strategy might be favorable for gut health in Crohn's disease, but at the cost of inducing symptoms. Read more »
Partial Enteral Nutrition (PEN) improves clinical symptoms, but Exclusive Enteral Nutrition (EEN) and Anti-Tumor Necrosis Factor Alpha (anti-TNF) are more effective for decreasing mucosal inflammation and improving specific aspects of quality of life. Read more »
Despite total, free, and bioavailable 25(OH)D concentrations being similar to those in a healthy control population, they inversely correlated strongly with intestinal inflammation. This was independent of potential malabsorption, sunlight exposure, and total vitamin D intake and obesity. Vitamin D may play an immunomodulatory role in IBD. Read more »
The dietary analysis method described provides a new tool for establishing relationships between diet and disease and indicates a potentially therapeutic diet for UC. Read more »
Intake of dietary fiber is associated with reduced disease flares in patients with Crohn's disease, but not UC. Read more »
Clinical and mucosal improvements were seen in children with CD, who used the Specific Carbohydrate Diet (SCD) for 12 and 52 weeks. Further studies are needed to understand the mechanisms underlying SCD's effectiveness in children with CD. Read more »
