We show reduced p38 MAPK activation in curcumin-treated mucosal biopsies, enhanced IL-10 and reduced IL-1b and demonstrate dose-dependent suppression of MMP-3 in CMF. We conclude that curcumin, a naturally occurring food substance with no known human toxicity, holds promise as a novel therapy in IBD. Read more »
Curcumin in combination with Mesalamine induces remission in patients with mild-to-moderate Ulcerative Colitis in a randomized controlled trial. Read more »
Addition of curcumin to mesalamine therapy was superior to the combination of placebo and mesalamine in inducing clinical and endoscopic remission in patients with mild-to-moderate active UC, producing no apparent adverse effects. Curcumin may be a safe and promising agent for treatment of UC. Read more »
In a controlled trial, seven of the ten Crohn's patients on an exclusion diet remained in remission, whereas zero of the ten not on the diet remained in remission. In an uncontrolled study of patients on an exclusion diet, 51 out of 77 remained in remission. Read more »
Consistently, colonic epithelial VDR levels are markedly reduced in patients with inflammatory bowel diseases or in experimental colitis models, whereas vitamin D analog therapy that ameliorates colitis up-regulates epithelial VDR. Thus, gut epithelial VDR signaling appears to play an essential role in controlling mucosal inflammation and thus could be a useful therapeutic target in the management of inflammatory bowel diseases. Read more »
In this study, men were fed diets with different amounts of meat each day for ten days. Researchers found that dietary protein from meat is an important substrate for sulfide generation by bacteria in the human large intestine. Read more »