Summarized in this report are the methods, major conclusions, and recommendations of the Scientific Report of the 2015 US Dietary Guidelines Advisory Committee (DGAC). One of their main conclusions was that consumption of vegetables, fruits, whole grains, and dairy tend to be low, and consumption of refined grains and added sugars are high, which puts people at increased risk for many chronic diseases. Read more »
This case series studied the Anti-Inflammatory Diet (IBD-AID) which restricts the intake of certain carbohydrates, includes the ingestion of pre- and probiotic foods, and modifies dietary fatty acids. The researchers concluded that the diet shows great potential in reducing inflammation, but needs a randomized clinical trial to confirm their results. Read more »
Using immunochip genotype data of individuals from Europe, East Asia, Iran and India, thirty-eight risk loci in IBD patients were recognized, 13 of which were first recognized in this study. There are some differences in the risk loci in Europeans versus non-Europeans, but there were three that were consistent in both: JAK2, IL23R and NKX2-3. Read more »
The myosin light chain kinase (MLCK) pathway controls intestinal epithelial barrier permeability by regulating the tight junction and 1,25-dihydroxyvitamin D (1,25(OH)2D3)-vitamin D receptor (VDR) signaling protects the epithelial barrier. These data demonstrate that 1,25(OH)2D3-VDR signaling preserves the mucosal barrier integrity by abrogating MLCK-dependent tight junction dysregulation during colonic inflammation. Read more »
Larger intake of fiber helps with inflammation in Crohn's patients but not UC patients. Read more »
Recent studies suggest that dietary therapy may be effective for patients with inflammatory bowel disease (IBD), but limited published data exist on the usage and efficacy of dietary therapy. Read more »
