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Crohn's Disease-Associated Adherent-Invasive Escherichia coli Adhesion Is Enhanced by Exposure to the Ubiquitous Dietary Polysaccharide Maltodextrin

n this study, the effect of a polysaccharide (specifically, MDX) panel on adhesiveness of the CD-associated AIEC strain LF82 was analyzed to determine if these food additives promote disease-associated bacterial phenotypes. The results show that MDX enhances E. coli adhesion and suggests a mechanism by which diets rich in specific polysaccharides may promote dysbiosis of gut microbes and contribute to disease susceptibility. Read more »

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

Using immunochip genotype data of individuals from Europe, East Asia, Iran and India, thirty-eight risk loci in IBD patients were recognized, 13 of which were first recognized in this study. There are some differences in the risk loci in Europeans versus non-Europeans, but there were three that were consistent in both: JAK2, IL23R and NKX2-3. Read more »

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Latest research findings regarding IBD