This study examined the lactulose-mannitol (LacMan) ratio in first-degree relatives of individuals with Crohn's Disease. Researchers found that the LacMan ratio was not significantly heritable suggesting that the contribution of genetic factors to the determination of intestinal permeability in healthy FDRs is modest. Read more »
n this study, the effect of a polysaccharide (specifically, MDX) panel on adhesiveness of the CD-associated AIEC strain LF82 was analyzed to determine if these food additives promote disease-associated bacterial phenotypes. The results show that MDX enhances E. coli adhesion and suggests a mechanism by which diets rich in specific polysaccharides may promote dysbiosis of gut microbes and contribute to disease susceptibility. Read more »
People born via Cesarean Section are not more likely to have IBD compared to controls or siblings without IBD. These findings indicate that events of the immediate postpartum period that shape the developing intestinal microbiome do not affect risk for IBD. Read more »
Using immunochip genotype data of individuals from Europe, East Asia, Iran and India, thirty-eight risk loci in IBD patients were recognized, 13 of which were first recognized in this study. There are some differences in the risk loci in Europeans versus non-Europeans, but there were three that were consistent in both: JAK2, IL23R and NKX2-3. Read more »