n this study, the effect of a polysaccharide (specifically, MDX) panel on adhesiveness of the CD-associated AIEC strain LF82 was analyzed to determine if these food additives promote disease-associated bacterial phenotypes. The results show that MDX enhances E. coli adhesion and suggests a mechanism by which diets rich in specific polysaccharides may promote dysbiosis of gut microbes and contribute to disease susceptibility. Read more »
In clinically quiescent Crohn's disease, altering dietary FODMAP intake is associated with marked changes in fecal microbiota, most consistent with a prebiotic effect of increasing FODMAPs as shown in an irritable bowel/healthy cohort. This strategy might be favorable for gut health in Crohn's disease, but at the cost of inducing symptoms. Read more »
Partial Enteral Nutrition (PEN) improves clinical symptoms, but Exclusive Enteral Nutrition (EEN) and Anti-Tumor Necrosis Factor Alpha (anti-TNF) are more effective for decreasing mucosal inflammation and improving specific aspects of quality of life. Read more »
Plasma metabolome of vegans differed markedly from omnivores but the gut microbiota was surprisingly similar. Unlike prior studies of individuals living in agrarian societies, higher consumption of fermentable substrate in vegans was not associated with higher levels of faecal short chain fatty acids. Read more »
Despite total, free, and bioavailable 25(OH)D concentrations being similar to those in a healthy control population, they inversely correlated strongly with intestinal inflammation. This was independent of potential malabsorption, sunlight exposure, and total vitamin D intake and obesity. Vitamin D may play an immunomodulatory role in IBD. Read more »
The dietary analysis method described provides a new tool for establishing relationships between diet and disease and indicates a potentially therapeutic diet for UC. Read more »
