IBD – nutrition
Curcumin for Inflammatory Bowel Disease: A Caution
Curcumin in combination with Mesalamine induces remission in patients with mild-to-moderate Ulcerative Colitis in a randomized controlled trial. Read more »
IBD – nutrition
Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial
Addition of curcumin to mesalamine therapy was superior to the combination of placebo and mesalamine in inducing clinical and endoscopic remission in patients with mild-to-moderate active UC, producing no apparent adverse effects. Curcumin may be a safe and promising agent for treatment of UC. Read more »
David Suskind
IBD – immunology
Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition
Curcumin inhibits microvascular endothelial cell angiogenesis through inhibition of COX-2 expression and PGE2 production, suggesting that this natural product possesses anti- angiogenic properties, which warrants further investigation as adjuvant treatment of IBD and cancer. Read more »
David Suskind
IBD – nutrition
Crohn's disease: maintenance of remission by diet.
In a controlled trial, seven of the ten Crohn's patients on an exclusion diet remained in remission, whereas zero of the ten not on the diet remained in remission. In an uncontrolled study of patients on an exclusion diet, 51 out of 77 remained in remission. Read more »
David Suskind
IBD – nutrition
Critical Roles of Intestinal Epithelial Vitamin D Receptor Signaling in Controlling Gut Mucosal Inflammation
Consistently, colonic epithelial VDR levels are markedly reduced in patients with inflammatory bowel diseases or in experimental colitis models, whereas vitamin D analog therapy that ameliorates colitis up-regulates epithelial VDR. Thus, gut epithelial VDR signaling appears to play an essential role in controlling mucosal inflammation and thus could be a useful therapeutic target in the management of inflammatory bowel diseases. Read more »
David Suskind
IBD – nutrition
Contribution of dietary protein to sulfide production in the large intestine: an in vitro and a controlled feeding study in humans
In this study, men were fed diets with different amounts of meat each day for ten days. Researchers found that dietary protein from meat is an important substrate for sulfide generation by bacteria in the human large intestine. Read more »
